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Article

Is there a role for inherited TRβ mutation in human carcinogenesis? [corrected].

Arquivos brasileiros de endocrinologia e metabologia - 1 Feb 2012

Weinert Letícia Schwerz, Ceolin Lucieli, Romitti Mírian, Camargo Eduardo Guimarães, Maia Ana Luiza

Abstract excerpt

Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited disorder characterized by end-organ reduced sensitivity to thyroid hormone. This syndrome is caused by mutations of the thyroid hormone receptor (TR) β gene, and its clinical presentation is quite variable. Goiter is reported to be the most common finding. A close association of TRβ mutations with human cancers has become apparent, but the...

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PMID: 22460197
DOI: 10.1590/s0004-27302012000100010

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