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Article

RNA Interference Mediated Inhibition of Dengue Virus Multiplication and Entry in HepG2 Cells

23 Mar 2012

Abstract excerpt

BACKGROUND: Dengue virus-host cell interaction initiates when the virus binds to the attachment receptors followed by endocytic internalization of the virus particle. Successful entry into the cell is necessary for infection initiation. Currently, there is no protective vaccine or antiviral treatment for dengue infection. Targeting the viral entry pathway has become an attractive therapeutic strategy to block...

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PMID: 22457813
DOI: 10.1371/journal.pone.0034060

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