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DNp73 improves generation efficiency of human induced pluripotent stem cells

26 Mar 2012

Abstract excerpt

BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53. However, p73 also has distinct properties of its own, such as two alternative promoters to express transactivation of p73 (TAp73) and N terminal deleted p73 (DNp73)....

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PMID: 22449255
DOI: 10.1186/1471-2121-13-9

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