Article
Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California.
The Journal of infectious diseases - 15 May 2012
Mehta Sanjay R, Kosakovsky Pond Sergei L, Young Jason A, Richman Douglas, Little Susan, Smith Davey M
Abstract excerpt
BACKGROUND: Specific sequence changes of human immunodeficiency virus type 1 (HIV-1) in the presence of specific HLA molecules may alter the composition and processing of viral peptides, leading to immune escape. Persistence of these mutations after transmission may leave the genetic fingerprint of the transmitter's HLA profile. Here, we evaluated the associations between HLA profiles and the phylogenetic...
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