Article
Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Nature - 21 Mar 2012
Cui Yujie, Wang Wei, Dong Ningzheng, Lou Jinglei, Srinivasan Dinesh Kumar, Cheng Weiwei, Huang Xiaoyi, Liu Meng, Fang Chaodong, Peng Jianhao, Chen Shenghan, Wu Shannon, Liu Zhenzhen, Dong Liang, Zhou Yiqing, Wu Qingyu
Abstract excerpt
In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear. Corin (also known as atrial natriuretic peptide-converting enzyme) is a...
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