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Article

How to infer reliable diploid genotypes from NGS or traditional sequence data: from basic probability to experimental optimization.

Journal of evolutionary biology - 1 May 2012

Chenuil A

Abstract excerpt

The use of diploid sequence markers is still challenging despite the good quality of the information they provide. There is a common problem to all sequencing approaches [traditional cloning and sequencing of PCR amplicons as well as next-generation sequencing (NGS)]: when no variation is found within the sequences from a given individual, homozygozity can never be asserted with certainty. As a consequence,...

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PMID: 22420488
DOI: 10.1111/j.1420-9101.2012.02488.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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