Article
Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures.
Molecular vision - 1 Jan 2012
Valyi-Nagy Klara, Kormos Bernadett, Ali Mohamed, Shukla Deepak, Valyi-Nagy Tibor
Abstract excerpt
PURPOSE: Cancer stem cells have increased resistance against a variety of anti-tumor treatment modalities. Vasculogenic mimicry (VM) patterns are present in numerous malignant tumor types, represent the formation of perfusion pathways by tumor cells, and their presence in tumors is associated with adverse outcome. Earlier we have shown that VM-forming tumor cells in three-dimensional (3D) uveal melanoma cultures...
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