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Article

Uveal melanoma cell lines contain stem-like cells that self-renew, produce differentiated progeny, and survive chemotherapy.

Investigative ophthalmology & visual science - 31 Oct 2011

Kalirai Helen, Damato Bertil E, Coupland Sarah E

Abstract excerpt

PURPOSE: Uveal melanoma (UM) cells in high-metastatic risk tumors have an undifferentiated molecular signature indicative of a more primitive cellular phenotype. Given mounting evidence for the existence of cancer stem cells (CSC), the authors investigated whether UM cell lines retain a population of self-renewing tumorigenic cells. METHODS: Single-cell cloning and spheroid culture studies were used to study the...

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Identifiers

PMID: 21896849
DOI: 10.1167/iovs.11-7379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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