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Article

Alteration of DNA demethylation dynamics by in vitro culture conditions in rabbit pre-implantation embryos

1 May 2012

Abstract excerpt

Alterations to DNA methylation have been attributed to in vitro culture and may affect normal embryo development. We chose to analyze DNA methylation reprogramming in the rabbit which, of the species with delayed transcriptional activation of the embryonic genome, allows easy comparisons between in vivo-developed (IVD) and in vitro-cultured (IVC) embryos. In this species, variations in DNA methylation had not...

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PMID: 22419129
DOI: 10.4161/epi.19563

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