Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle.

Abstract excerpt

Myosin binding protein-C (MyBP-C), a major thick filament associated sarcomeric protein, plays an important functional and structural role in regulating sarcomere assembly and crossbridge formation. Missing or aberrant MyBP-C proteins (both cardiac and skeletal) have been shown to cause both cardiac and skeletal myopathies, thereby emphasising its importance for the normal functioning of the sarcomere. Mutations...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arthrogryposis
• Share to Cardiomyopathy, Hypertrophic