Article
Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.
The Journal of molecular diagnostics : JMD - 1 Jan 2000
Dijkstra Jeroen R, Opdam Frank J M, Boonyaratanakornkit Jerry, Schönbrunner E Ralf, Shahbazian Mona, Edsjö Anders, Hoefler Gerald, Jung Andreas, Kotsinas Athanassios, Gorgoulis Vassilis G, López-Ríos Fernando, de Stricker Karin, Rouleau Etienne, Biesmans Bart, van Krieken J Han J M
Abstract excerpt
In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not carry a mutation in...
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