Article
EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy.
Journal of clinical pathology - 1 Oct 2011
Thunnissen Erik, Bovée Judith V M G, Bruinsma Hans, van den Brule Adriaan J C, Dinjens Winand, Heideman Daniëlle A M, Meulemans Els, Nederlof Petra, van Noesel Carel, Prinsen Clemens F M, Scheidel Karen, van de Ven Peter M, de Weger Roel, Schuuring Ed, Ligtenberg Marjolijn
Abstract excerpt
INTRODUCTION: The aim of this study was to compare the reproducibility of epidermal growth factor receptor (EGFR) immunohistochemistry (IHC), EGFR gene amplification analysis, and EGFR and KRAS mutation analysis among different laboratories performing routine diagnostic analyses in pathology in The Netherlands, and to generate normative data. METHODS: In 2008, IHC, in-situ hybridisation (ISH) for EGFR, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.