Article
Regulation Where Autophagy Intersects the Inflammasome
5 May 2013
Abstract excerpt
SIGNIFICANCE: The autophagy and inflammasome pathways are ancient innate immune mechanisms for controlling invading pathogens that are linked by mutual regulation. In addition to controlling the metabolic homeostasis of the cell through nutrient recycling, the "self-eating" process of autophagy is also responsible for the degradation of damaged organelles, cells, and pathogens to protect the integrity of the...