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Article

Autophagy limits activation of the inflammasomes

16 Dec 2017

Abstract excerpt

Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. Therefore, inflammasomes must be activated at a proper strength to protect against infection and...

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PMID: 29248000
DOI: 10.1111/imr.12613

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