High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.

doi:10.1158/1535-7163.MCT-11-0899

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Article

High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.

Molecular cancer therapeutics - 1 May 2012

Levallet Guénaëlle, Bergot Emmanuel, Antoine Martine, Creveuil Christian, Santos Adriana O, Beau-Faller Michelle, de Fraipont Florence, Brambilla Elisabeth, Levallet Jérôme, Morin Franck, Westeel Virginie, Wislez Marie, Quoix Elisabeth, Debieuvre Didier, Dubois Fatéméh, Rouquette Isabelle, Pujol Jean-Louis, Moro-Sibilot Denis, Camonis Jacques, Zalcman Gérard

Abstract excerpt

We assessed the prognostic and predictive value of β-tubulin III (TUBB3) expression, as determined by immunohistochemistry, in 412 non-small cell lung cancer (NSCLC) specimens from early-stage patients who received neoadjuvant chemotherapy (paclitaxel- or gemcitabine-based) in a phase III trial (IFCT-0002). We also correlated TUBB3 expression with K-Ras and EGF receptor (EGFR) mutations in a subset of 208...

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Identifiers

PMID: 22411898
DOI: 10.1158/1535-7163.MCT-11-0899

Genes

TUBB3
EGF
EGFR

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