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Article

Cerebral lactic acidosis correlates with neurological impairment in MELAS

28 Dec 2004

Abstract excerpt

To evaluate the role of chronic cerebral lactic acidosis in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).The authors studied 91 individuals from 34 families with MELAS and the A3243G point mutation and 15 individuals from two families with myoclonus epilepsy and ragged red fibers (MERRF) and the A8344G mutation. Subjects were divided into four groups. Paternal relatives were...

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PMID: 15623741
DOI: 10.1212/wnl.63.12.2458

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