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Article

Detection of low allele burden of JAK2 exon 12 mutations using TA-cloning in patients with erythrocytosis.

Japanese journal of clinical oncology - 1 Aug 2009

Ohyashiki Junko H, Hisatomi Hisashi, Shimizu Syoko, Sugaya Maki, Ohyashiki Kazuma

Abstract excerpt

OBJECTIVE: Polycythemia vera (PV) is a clonal myeloproliferative neoplasia associated with the activation of the Janus-activating kinase 2 (JAK2) mutation. The aim of this study is to identify clonal expansion of exon 12 mutations. METHODS: We performed DNA sequencing of the JAK2 exon 12 after TA-cloning in JAK2-V617F-negative and JAK2-V617F-positive PV patients. RESULTS AND CONCLUSIONS: We found clonal mutations...

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Identifiers

PMID: 19491085
DOI: 10.1093/jjco/hyp048

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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