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Article

Recombinant influenza A viruses with enhanced levels of PB1 and PA viral protein expression.

Journal of virology - 1 May 2012

Belicha-Villanueva Alan, Rodriguez-Madoz Juan R, Maamary Jad, Baum Alina, Bernal-Rubio Dabeiba, Minguito de la Escalera Maria, Fernandez-Sesma Ana, García-Sastre Adolfo

Abstract excerpt

Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruses is attenuated, and they have an enhanced shedding of noninfectious particles and are incapable of antagonizing interferon (IFN) effectively. Our findings highlight...

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Share to Gene Expression Regulation, Viral
Share to Influenza A virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22398284
DOI: 10.1128/JVI.06384-11
PMCID: PMC3347261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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