Article
Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011
Akkiz Hikmet, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin, Üsküdar Oğuz
Abstract excerpt
MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs with posttranscriptional regulatory functions as tumor suppressors and oncogenes. It has been suggested that the presence of single nucleotide polymorphisms (SNPs) in miRNAs can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to susceptibility to cancer...
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