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Article

Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase.

PloS one - 1 Jan 2012

Tran Quang M, Fong Carmen, Rothery Richard A, Maklashina Elena, Cecchini Gary, Weiner Joel H

Abstract excerpt

The role of the heme b in Escherichia coli succinate dehydrogenase is highly ambiguous and its role in catalysis is questionable. To examine whether heme reduction is an essential step of the catalytic mechanism, we generated a series of site-directed mutations around the heme binding pocket, creating a library of variants with a stepwise decrease in the midpoint potential of the heme from the wild-type value of...

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Identifiers

PMID: 22393428
DOI: 10.1371/journal.pone.0032641
PMCID: PMC3290573

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Source receipt: pubmed, retrieved 7 Sept 2026.

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