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Article

Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions.

PloS one - 1 Jan 2012

Seixas Susana, Ivanova Nevyana, Ferreira Zelia, Rocha Jorge, Victor Bruno L

Abstract excerpt

Serine protease inhibitors (SERPINs) are crucial in the regulation of diverse biological processes including inflammation and immune response. SERPINB11, located in the 18q21 gene cluster, is a polymorphic gene/pseudogene coding for a non-inhibitory SERPIN. In a genome-wide scan for recent selection, SERPINB11 was identified as a potential candidate gene for adaptive evolution in Yoruba. The present study sought...

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Identifiers

PMID: 22393410
DOI: 10.1371/journal.pone.0032518
PMCID: PMC3290568

Genes

SERPINB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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