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Article

The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila.

PloS one - 1 Jan 2012

Kanao Tomoko, Sawada Tomoyo, Davies Shireen-Anne, Ichinose Hiroshi, Hasegawa Kazuko, Takahashi Ryosuke, Hattori Nobutaka, Imai Yuzuru

Abstract excerpt

Activation of the forkhead box transcription factor FoxO is suggested to be involved in dopaminergic (DA) neurodegeneration in a Drosophila model of Parkinson's disease (PD), in which a PD gene product LRRK2 activates FoxO through phosphorylation. In the current study that combines Drosophila gen...

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Identifiers

PMID: 22393355
DOI: 10.1371/journal.pone.0030958
PMCID: PMC3290610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22393355-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila.PMID 22393355Read ↗

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FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigraSemantic proximity Read ↗

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.Semantic proximity Read ↗

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