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Article

Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.

PLoS genetics - 1 Mar 2018

Tas Damla, Stickley Luca, Miozzo Federico, Koch Rafael, Loncle Nicolas, Sabado Virginie, Gnägi Bettina, Nagoshi Emi

Abstract excerpt

Forkhead box (FOXO) proteins are evolutionarily conserved, stress-responsive transcription factors (TFs) that can promote or counteract cell death. Mutations in FOXO genes are implicated in numerous pathologies, including age-dependent neurodegenerative disorders, such as Parkinson's disease (PD). However, the complex regulation and downstream mechanisms of FOXOs present a challenge in understanding their roles...

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Identifiers

PMID: 29529025
DOI: 10.1371/journal.pgen.1007271
PMCID: PMC5864087

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PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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