Article
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2008
Gaballa Ahmed, Antelmann Haike, Aguilar Claudio, Khakh Sukhjit K, Song Kyung-Bok, Smaldone Gregory T, Helmann John D
Abstract excerpt
Regulation of bacterial iron homeostasis is often controlled by the iron-sensing ferric uptake repressor (Fur). The Bacillus subtilis Fur protein acts as an iron-dependent repressor for siderophore biosynthesis and iron transport proteins. Here, we demonstrate that Fur also coordinates an iron-sparing response that acts to repress the expression of iron-rich proteins when iron is limiting. When Fur is inactive,...
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