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Article

Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 2012

Kohno Shohei, Yamashita Yui, Abe Tomoki, Hirasaka Katsuya, Oarada Motoko, Ohno Ayako, Teshima-Kondo Shigetada, Higashibata Akira, Choi Inho, Mills Edward M, Okumura Yuushi, Terao Junji, Nikawa Takeshi

Abstract excerpt

Skeletal muscle is one of the most sensitive tissues to mechanical loading, and unloading inhibits the regeneration potential of skeletal muscle after injury. This study was designed to elucidate the specific effects of unloading stress on the function of immunocytes during muscle regeneration after injury. We examined immunocyte infiltration and muscle regeneration in cardiotoxin (CTX)-injected soleus muscles of...

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Identifiers

PMID: 22383511
DOI: 10.1152/japplphysiol.00103.2012
PMCID: PMC3785183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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