Article
Polymorphisms of SPRN (shadow of prion protein homology) in three breeds of sheep in China.
Virus genes - 1 Jun 2012
Zhang Xaioli, Zhou Xiangmei, Ding Tianjian, Gan Wenqiang, Yang Lifeng, Yin Xiaomin, Zhao Deming
Abstract excerpt
The key point, which is related to the susceptibility of prion diseases in animals, has been proved to be the prion protein gene (PRNP). However, animals, especially sheep and goats, with the same PRNP genotype are not equally susceptible to the diseases. The finding of SPRN (shadow of prion protein homology) provides a new aspect to understand the diseases as protein of SPRN (Shadoo) has similar neuroprotective...
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