Article
Flower-deficient mice have reduced susceptibility to skin papilloma formation.
Disease models & mechanisms - 1 Jul 2012
Petrova Evgeniya, López-Gay Jesús M, Rhiner Christa, Moreno Eduardo
Abstract excerpt
Skin papillomas arise as a result of clonal expansion of mutant cells. It has been proposed that the expansion of pretumoral cell clones is propelled not only by the increased proliferation capacity of mutant cells, but also by active cell selection. Previous studies in Drosophila describe a clonal selection process mediated by the Flower (Fwe) protein, whereby cells that express certain Fwe isoforms are...
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