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Article

Investigation of rifampicin resistance mechanisms in Brucella abortus using MS-driven comparative proteomics.

Journal of proteome research - 6 Apr 2012

Sandalakis Vassilios, Psaroulaki Anna, De Bock Pieter-Jan, Christidou Athanasia, Gevaert Kris, Tsiotis Georgios, Tselentis Yiannis

Abstract excerpt

Mutations in the rpoB gene have already been shown to contribute to rifampicin resistance in many bacterial strains including Brucella species. Resistance against this antibiotic easily occurs and resistant strains have already been detected in human samples. We here present the first research project that combines proteomic, genomic, and microbiological analysis to investigate rifampicin resistance in an in...

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Brucella abortus
Computer Simulation
Drug Resistance, Bacterial
Mass Spectrometry
Protein Interaction Maps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22360387
DOI: 10.1021/pr201122w

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