Article
[A new method of quantitative estimation of mutant allele in mitochondrial genome].
Patologicheskaia fiziologiia i eksperimental'naia terapiia - 1 Jan 2000
Sazonova M A, Postnov A Iu, Orekhov A N, sobenin I A
Abstract excerpt
A new original method of quantitative estimation of heteroplasmy levels in mitochondrial genome is necessary for determination cut-of values mutant allele in tissues, associated with the emergence and development of pathologies in human organism. This method is based on pyrosequencing of short DNA fragments. It is characterized by high accuracy and good reproducibility and helps to find out crucial differences in...
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