Article
The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population.
Clinical endocrinology - 1 Jul 2012
Capalbo A, Sagnella F, Apa R, Fulghesu A M, Lanzone A, Morciano A, Farcomeni A, Gangale M F, Moro F, Martinez D, Ciardulli A, Palla C, Uras M L, Spettu F, Cappai A, Carcassi C, Neri G, Tiziano F D
Abstract excerpt
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive. DESIGN: Case-control study aimed at evaluating possible associations between...
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