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Article

Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus

13 Jun 2011

Abstract excerpt

HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA binding. More importantly, NS3(pro) binding to the SLIV hinders the interaction of La protein, a cellular IRES-trans...

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PMID: 22355520
DOI: 10.1038/srep00001

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