Article
The role of DNA damage and repair in aging through the prism of Koch-like criteria.
Ageing research reviews - 1 Mar 2013
Moskalev Alexey A, Shaposhnikov Mikhail V, Plyusnina Ekaterina N, Zhavoronkov Alex, Budovsky Arie, Yanai Hagai, Fraifeld Vadim E
Abstract excerpt
Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great volume of knowledge in the field has been accumulated. Here we attempted to organize the evidence "for" and "against" the hypothesized causal role of DNA damage and mutation accumulation in aging in light of four Koch-like criteria. They are based on the assumption that some quantitative relationship between the levels of DNA...
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