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Article

myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei.

The Journal of biological chemistry - 13 Apr 2012

Gonzalez-Salgado Amaia, Steinmann Michael E, Greganova Eva, Rauch Monika, Mäser Pascal, Sigel Erwin, Bütikofer Peter

Abstract excerpt

myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via myo-inositol symporters. We show that in Trypanosoma brucei, the causative pathogen of human African sleeping sickness and nagana in domestic animals, myo-inositol...

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Identifiers

PMID: 22351763
DOI: 10.1074/jbc.M112.344812
PMCID: PMC3340000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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