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Article

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

PLoS pathogens - 1 Feb 2012

Marcinowski Lisa, Tanguy Mélanie, Krmpotic Astrid, Rädle Bernd, Lisnić Vanda J, Tuddenham Lee, Chane-Woon-Ming Béatrice, Ruzsics Zsolt, Erhard Florian, Benkartek Corinna, Babic Marina, Zimmer Ralf, Trgovcich Joanne, Koszinowski Ulrich H, Jonjic Stipan, Pfeffer Sébastien, Dölken Lars

Abstract excerpt

Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report that this regulation is mediated by the ∼1.7 kb spliced and highly abundant MCMV m169 transcript. Specificity to...

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Identifiers

PMID: 22346748
DOI: 10.1371/journal.ppat.1002510
PMCID: PMC3276556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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