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Article

Gut Barrier Dysfunction-A Primary Defect in Twins with Crohn's Disease Predominantly Caused by Genetic Predisposition.

Journal of Crohn's & colitis - 9 Nov 2018

Keita Åsa V, Lindqvist Carl Mårten, Öst Åke, Magana Carlos D L, Schoultz Ida, Halfvarson Jonas

Abstract excerpt

Background and Aims: The aetiology of Crohn's disease is poorly understood. By investigating twin pairs discordant for Crohn's disease, we aimed to assess whether the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15 twin pairs discordant for Crohn's disease [monozygotic n = 9,...

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Identifiers

PMID: 29659773
DOI: 10.1093/ecco-jcc/jjy045
PMCID: PMC6225972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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