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Article

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

24 Nov 2020

Abstract excerpt

Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced...

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PMID: 33232318
DOI: 10.1371/journal.pbio.3000926

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