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Article

Hfq and Hfq-dependent small RNAs are major contributors to multicellular development in Salmonella enterica serovar Typhimurium.

RNA biology - 1 Apr 2012

Monteiro Claudia, Papenfort Kai, Hentrich Karina, Ahmad Irfan, Le Guyon Soazig, Reimann Romy, Grantcharova Nina, Römling Ute

Abstract excerpt

The RNA chaperone Hfq and its associated small RNAs (sRNAs) regulate a variety of phenotypes in bacteria. In this work, we show that Hfq is a master regulator of biofilm formation in Salmonella enterica serovar Typhimurium. Hfq and two Hfq-dependent sRNAs (ArcZ and SdsR) are required for rdar morphotype expression in S. typhimurium. Hfq controls rdar biofilm formation through the major biofilm regulator CsgD....

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PMID: 22336758
DOI: 10.4161/rna.19682

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