MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.

doi:10.18632/oncotarget.10577

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MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.

Oncotarget - 23 Aug 2016

Leoncini Pier Paolo, Bertaina Alice, Papaioannou Dimitrios, Flotho Christian, Masetti Riccardo, Bresolin Silvia, Menna Giuseppe, Santoro Nicola, Zecca Marco, Basso Giuseppe, Nigita Giovanni, Veneziano Dario, Pagotto Sara, D'Ovidio Katia, Rota Rossella, Dorrance Adrienne, Croce Carlo M, Niemeyer Charlotte, Locatelli Franco, Garzon Ramiro

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is an aggressive leukemia of early childhood characterized by aberrant proliferation of myelomonocytic cells and hypersensitivity to GM-CSF stimulation. Mutually exclusive mutations in the RAS/ERK pathway genes such as PTPN11, NRAS, KRAS, CBL, or NF1 are found in ~90% of the cases. These mutations give rise to disease at least in part by activating STAT5 through...

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Identifiers

PMID: 27447965
DOI: 10.18632/oncotarget.10577
PMCID: PMC5342425

Genes

CBL
KRAS
NRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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