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Article

Identification and characterization of an injury-induced skeletal progenitor.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015

Marecic Owen, Tevlin Ruth, McArdle Adrian, Seo Eun Young, Wearda Taylor, Duldulao Christopher, Walmsley Graham G, Nguyen Allison, Weissman Irving L, Chan Charles K F, Longaker Michael T

Abstract excerpt

The postnatal skeleton undergoes growth, remodeling, and repair. We hypothesized that skeletal progenitor cells active during these disparate phases are genetically and phenotypically distinct. We identified a highly potent regenerative cell type that we term the fracture-induced bone, cartilage, stromal progenitor (f-BCSP) in the fracture callus of adult mice. The f-BCSP possesses significantly enhanced...

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Identifiers

PMID: 26216955
DOI: 10.1073/pnas.1513066112
PMCID: PMC4538608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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