Article
Alleles that modulate late life hearing in genetically heterogeneous mice.
Neurobiology of aging - 1 Aug 2012
Schacht Jochen, Altschuler Richard, Burke David T, Chen Shu, Dolan David, Galecki Andrzej T, Kohrman David, Miller Richard A
Abstract excerpt
A genetically heterogeneous population of mice was tested for hearing at 8, 18, and 22 months by auditory brainstem response (ABR), and genotyped at 128 markers to identify loci that modulate late life hearing loss. Half of the test mice were exposed to noise for 2 hours at age 20 months. Polymorphisms affecting hearing at 18 months were noted on chromosomes 2, 3, 7, 10, and 15. Most of these loci had effects...
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