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Article

Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.

The Journal of biological chemistry - 16 Mar 2012

Wu Kailang, Peng Guiqing, Wilken Matthew, Geraghty Robert J, Li Fang

Abstract excerpt

The severe acute respiratory syndrome coronavirus (SARS-CoV) from palm civets has twice evolved the capacity to infect humans by gaining binding affinity for human receptor angiotensin-converting enzyme 2 (ACE2). Numerous mutations have been identified in the receptor-binding domain (RBD) of different SARS-CoV strains isolated from humans or civets. Why these mutations were naturally selected or how SARS-CoV...

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Identifiers

PMID: 22291007
DOI: 10.1074/jbc.M111.325803
PMCID: PMC3308800

Genes

ACE2

Provenance

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