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Article

Chromosome aberrations induced by etoposide (VP-16) are not random.

International journal of cancer - 15 Nov 1990

Maraschin J, Dutrillaux B, Aurias A

Abstract excerpt

The clastogenic effect of etoposide, an anti-cancer chemotherapeutic drug, was investigated in vitro on lymphocytes of 5 healthy donors. The analysis of the first division metaphases arising after mutagenesis in G1 phase shows that chromosome-type aberrations are much more frequent than chromatid-type lesions. The distribution in relation to chromosome lengths of the 439 breakpoints that were accurately...

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Identifiers

PMID: 2228309
DOI: 10.1002/ijc.2910460511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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