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Article

Low level of DNA repair in human chromosome 1 heterochromatin

1 Oct 1997

Abstract excerpt

Band 1q12 is a breakage prone region commonly involved in chromosome 1 rearrangements found in human cancer. We have investigated whether a lack of DNA repair can account for the observed 1q12 fragility. Ethyl methanesulfonate (EMS)-induced repair sites originating in G0/G1 phase of the cell cycle were converted to chromosome breaks by blocking the re-synthesis step of excision repair with cytosine arabinoside....

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PMID: 9331568
DOI: 10.1002/(sici)1098-2264(199710)20:2<173::aid-gcc8>3.0.co;2-0

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