Article
The role of animal models in unravelling therapeutic targets in coeliac disease.
Best practice & research. Clinical gastroenterology - 1 Jun 2015
Costes Léa M M, Meresse Bertrand, Cerf-Bensussan Nadine, Samsom Janneke N
Abstract excerpt
Coeliac disease is a complex small intestinal enteropathy that develops consequently to a breach of tolerance to gliadin, a storage protein abundantly found in cereals such as wheat, rye and barley. The understanding of the mechanisms underlying the development of coeliac disease in HLA-DQ2 and HLA-DQ8 genetically susceptible individuals has greatly improved during the last decades but so far did not allow to...
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