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Article

Thiazolidinedione response in familial lipodystrophy patients with LMNA mutations: a case series.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Apr 2012

Luedtke A, Boschmann M, Colpe C, Engeli S, Adams F, Birkenfeld A L, Haufe S, Rahn G, Luft F C, Schmidt H H-J, Jordan J

Abstract excerpt

Type 2 familial partial lipodystrophy (FPLD2) patients show impaired glucose and lipid metabolism resulting from lipodystrophic 'lipid pressure' and an intrinsic defect in skeletal muscle metabolism. Since mutated lamin A may interfere with peroxisome proliferator activator gamma (PPARγ) expression, we hypothesized that PPARγ stimulation improves fat distribution and metabolic abnormalities in these patients. 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22274718
DOI: 10.1055/s-0031-1301284

Genes

LMNA

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Thiazolidinedione response in familial lipodystrophy patients with LMNA mutations: a case series.PMID 22274718Read ↗

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Clinical characteristics and efficacy of pioglitazone in a Japanese patient with familial partial lipodystrophy due to peroxisome proliferator-activated receptor γ gene mutation.Semantic proximity Read ↗

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