Article
LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance.
The Journal of clinical endocrinology and metabolism - 1 Apr 2010
Boschmann Michael, Engeli Stefan, Moro Cedric, Luedtke Angelika, Adams Frauke, Gorzelniak Kerstin, Rahn Gabriele, Mähler Anja, Dobberstein Kerstin, Krüger Antje, Schmidt Saskia, Spuler Simone, Luft Friedrich C, Smith Steven R, Schmidt Hartmut H-J, Jordan Jens
Abstract excerpt
CONTEXT: Type 2 familial partial lipodystrophy (FPLD) is an autosomal-dominant lamin A/C-related disease associated with exercise intolerance, muscular pain, and insulin resistance. The symptoms may all be explained by defective metabolism; however, metabolism at the tissue level has not been inv...
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