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Article

Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells.

Clinical & experimental metastasis - 1 Apr 2012

Castilla Carolina, Flores M Luz, Conde José M, Medina Rafael, Torrubia Francisco J, Japón Miguel A, Sáez Carmen

Abstract excerpt

PTPL1, a non-receptor type protein tyrosine phosphatase, has been involved in the regulation of apoptosis and invasiveness of various tumour cell types, but its role in prostate cancer remained to be investigated. We report here that downregulation of PTPL1 by small interfering RNA in PC3 cells d...

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Source

Identifiers

PMID: 22274591
DOI: 10.1007/s10585-012-9455-7

Genes

PCNA
PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22274591-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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