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Article

Evidence of genetic association between TNFRSF1A encoding the p55 tumour necrosis factor receptor, and ankylosing spondylitis in UK Caucasians.

Clinical and experimental rheumatology - 1 Jan 2000

Karaderi T, Pointon J J, Wordsworth T W H, Harvey D, Appleton L H, Cohen C J, Farrar C, Harin A, Brown M A, Wordsworth B P

Abstract excerpt

OBJECTIVES: To replicate the possible genetic association between ankylosing spondylitis (AS) and TNFRSF1A. METHODS: TNFRSF1A was re-sequenced in 48 individuals with AS to identify novel polymorphisms. Nine single nucleotide polymorphisms (SNPs) in TNFRSF1A and 5 SNPs in the neighbouring gene SCNN1A were genotyped in 1604 UK Caucasian individuals with AS and 1019 matched controls. An extended study was...

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PMID: 22272576

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