Article
Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics.
PloS one - 1 Jan 2012
Nagaraj Ram H, Panda Alok Kumar, Shanthakumar Shilpa, Santhoshkumar Puttur, Pasupuleti NagaRekha, Wang Benlian, Biswas Ashis
Abstract excerpt
Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modification of αA-crystallin increased its chaperone function. We identified MGO-modified arginine residues in αA-crystallin and found that replacing such arginine...
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