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Article

SBDS protein expression patterns in the bone marrow.

Pediatric blood & cancer - 1 Sept 2010

Wong Trisha E, Calicchio Monica L, Fleming Mark D, Shimamura Akiko, Harris Marian H

Abstract excerpt

Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome caused by biallelic SBDS gene mutations. Here we examined SBDS protein levels in human bone marrow. SBDS protein expression was high in neutrophil progenitors, megakaryocytes, plasma cells, and osteoblasts. In contrast, SBDS protein levels were low in all hematopoietic cell lineages from patients harboring the common SBDS mutations. We...

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Source

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Identifiers

PMID: 20658628
DOI: 10.1002/pbc.22573
PMCID: PMC2913690

Genes

SBDS
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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